Dynamic Strength of Titin's Z-Disk End

نویسندگان

  • Veronika Kollár
  • Dávid Szatmári
  • László Grama
  • Miklós S. Z. Kellermayer
چکیده

Titin is a giant filamentous protein traversing the half sarcomere of striated muscle with putative functions as diverse as providing structural template, generating elastic response, and sensing and relaying mechanical information. The Z-disk region of titin, which corresponds to the N-terminal end of the molecule, has been thought to be a hot spot for mechanosensing while also serving as anchorage for its sarcomeric attachment. Understanding the mechanics of titin's Z-disk region, particularly under the effect of binding proteins, is of great interest. Here we briefly review recent findings on the structure, molecular associations, and mechanics of titin's Z-disk region. In addition, we report experimental results on the dynamic strength of titin's Z1Z2 domains measured by nanomechanical manipulation of the chemical dimer of a recombinant protein fragment.

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عنوان ژورنال:

دوره 2010  شماره 

صفحات  -

تاریخ انتشار 2010